For vaccination of healthy, susceptible swine 3 weeks of age or older as an aid in the reduction of disease caused by Mycoplasmahyopneumoniae, and as an aid in the prevention of respiratory disease due to Porcine Reproductive and Respiratory Syndrome (PRRS) virus. Indicated for use in PRRS virus positive herds only. The duration of immunity against M. hyopneumoniae is at least 26 weeks. The duration of immunity against PRRS is at least 4 months, which is throughout gestation for sows and gilts, or throughout the finishing period for pigs.