For the vaccination of healthy, susceptible swine 3 weeks of age or older as an aid in the prevention of lymphoid depletion, inflammation and colonization of lymphoid tissue associated with Porcine Circovirus Type 2 (PCV2), and as an aid in the prevention of disease caused Mycoplasma hyopneumoniae. The onset of protection against Porcine Circovirus Type 2 is 2 weeks post-vaccination, and the duration of immunity is at least 4 months. The duration of immunity against M.hyopneumoniae is at least 26 weeks.